抄録
An enzymatically enantioselective ester hydrolysis of prochiral 1,3-diacyloxy-2-substituted-2-propanol to chiral 1-acyloxy-2,3-propanediol was studied. The (R)-monoester was prepared by selection of a suitable lipase and alkyl chain length of the substrate diester. Lipase D from Rhizopus delemer gave (R)-1-isobutyryloxy-2-(2,4-difluorophenyl)-2,3-propanediol with 97%ee and 87% yield at 15°C and pH 5.5. The (R)-monoester is a key intermediate of azole antifungal agents.
| 本文言語 | English |
|---|---|
| ページ（範囲） | 2044-2049 |
| ページ数 | 6 |
| ジャーナル | Bioscience, Biotechnology and Biochemistry |
| 巻 | 65 |
| 号 | 9 |
| DOI | |
| 出版ステータス | Published - 2001 9月 |
| 外部発表 | はい |
ASJC Scopus subject areas
- バイオテクノロジー
- 分析化学
- 生化学
- 応用微生物学とバイオテクノロジー
- 分子生物学
- 有機化学