Eph and ephrin interactions in bone

研究成果: Conference contribution

32 被引用数 (Scopus)

抄録

Bone cells communicate with each other using various cell surface molecules. Membrane-bound ephrin ligands and Eph tyrosine kinase receptors have been characterized in diverse biological processes, including angiogenesis and neuronal development. Several ephrins and Ephs are expressed in osteoclasts and osteoblasts and regulate bone mineral metabolism through bidirectional signaling into not only receptor-expressing cells but also into ligand-expressing cells. We propose that interaction between ephrinB2-expressing osteoclasts and EphB4-expressing osteoblasts facilitates the transition from bone resorption to bone formation during bone remodeling. Other groups have reported the regulation of ephrinB2 by PTH or PTHrP and the possible involvement of EphB4 in osteoarthritis. It is likely that various ephrins and Ephs mediate interaction among bone cells.

本文言語English
ホスト出版物のタイトルOsteoimmunology
ホスト出版物のサブタイトルInteractions of the Immune and Skeletal Systems II
編集者Yongwon Choi
ページ95-103
ページ数9
DOI
出版ステータスPublished - 2010 12月 1

出版物シリーズ

名前Advances in Experimental Medicine and Biology
658
ISSN(印刷版)0065-2598

ASJC Scopus subject areas

  • 生化学、遺伝学、分子生物学(全般)

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