Epidermal barrier dysfunction and cutaneous sensitization in atopic diseases

Akiharu Kubo, Keisuke Nagao, Masayuki Amagai

研究成果: Review article査読

241 被引用数 (Scopus)

抄録

Classic atopic dermatitis is complicated by asthma, allergic rhinitis, and food allergies, cumulatively referred to as atopic diseases. Recent discoveries of mutations in the filaggrin gene as predisposing factors for atopic diseases have refocused investigators' attention on epidermal barrier dysfunction as a causative mechanism. The skin's barrier function has three elements: the stratum corneum (air-liquid barrier), tight junctions (liquid-liquid barrier), and the Langerhans cell network (immunological barrier). Clarification of the molecular events underpinning epidermal barrier function and dysfunction should lead to a better understanding of the pathophysiological mechanisms of atopic diseases.

本文言語English
ページ(範囲)440-447
ページ数8
ジャーナルJournal of Clinical Investigation
122
2
DOI
出版ステータスPublished - 2012 2月

ASJC Scopus subject areas

  • 医学(全般)

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