Epidermal cell turnover across tight junctions based on Kelvin’s tetrakaidecahedron cell shape

Mariko Yokouchi, Toru Atsugi, Mark Van Logtestijn, Reiko J. Tanaka, Mayumi Kajimura, Makoto Suematsu, Mikio Furuse, Masayuki Amagai, Akiharu Kubo

研究成果: Article査読

54 被引用数 (Scopus)

抄録

In multicellular organisms, cells adopt various shapes, from flattened sheets of endothelium to dendritic neurons, that allow the cells to function effectively. Here, we elucidated the unique shape of cells in the cornified stratified epithelia of the mammalian epidermis that allows them to achieve homeostasis of the tight junction (TJ) barrier. Using intimate in vivo 3D imaging, we found that the basic shape of TJ-bearing cells is a flattened Kelvin’s tetrakaidecahedron (f-TKD), an optimal shape for filling space. In vivo live imaging further elucidated the dynamic replacement of TJs on the edges of f-TKD cells that enables the TJ-bearing cells to translocate across the TJ barrier. We propose a spatiotemporal orchestration model of f-TKD cell turnover, where in the classic context of’form follows function’, cell shape provides a fundamental basis for the barrier homeostasis and physical strength of cornified stratified epithelia.

本文言語English
論文番号e19593
ジャーナルeLife
5
NOVEMBER2016
DOI
出版ステータスPublished - 2016 11月 29

ASJC Scopus subject areas

  • 神経科学(全般)
  • 免疫学および微生物学(全般)
  • 生化学、遺伝学、分子生物学(全般)

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