Epigenetic activation of tumor suppressor microRNAs in human cancer cells

Yoshimasa Saito, Peter A. Jones

研究成果: Short survey査読

235 被引用数 (Scopus)

抄録

MicroRNAs (miRNAs) are small non-coding RNAs that function as endogenous posttranscriptional silencers of target genes. miRNAs are expressed in a tissue specific manner and play important roles in cell proliferation, apoptosis and differentiation during animal development. Recent studies have shown a distinct connection between aberrant expression of miRNAs and the development of cancer, suggesting that miRNAs can be potential therapeutic targets. Our recent study has shown that some miRNAs are controlled by epigenetic alterations such as DNA methylation and histone modification in human cancer cells. Activation of tumor suppressor miRNAs by chromatin modifying drugs may cause downregulation of target oncogenes and could be a novel strategy for the prevention and treatment of human cancer.

本文言語English
ページ(範囲)2220-2222
ページ数3
ジャーナルCell Cycle
5
19
DOI
出版ステータスPublished - 2006 10 1
外部発表はい

ASJC Scopus subject areas

  • 分子生物学
  • 発生生物学
  • 細胞生物学

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