Epigenetic mechanisms in sequential differentiation of neural stem cells

Tsukasa Sanosaka, Masakazu Namihira, Kinichi Nakashima

研究成果: Review article査読

27 被引用数 (Scopus)

抄録

The major cell types in the central nervous system, neurons and glial cells (astrocytes and oligodendrocytes), are generated from common neural stem cells (NSCs). However, neurogenesis precedes gliogenesis, which normally commences at later stages of fetal brain development. Recent studies have shown that epigenetic gene regulation, in concert with cues from outside the cells, plays important roles in regulating the differentiation potential and fate specification of NSCs. In this review, we discuss emerging molecular explanations for the transitions that occur during the stepwise process of NSC fate specification.

本文言語English
ページ(範囲)89-92
ページ数4
ジャーナルEpigenetics
4
2
DOI
出版ステータスPublished - 2009 2 16
外部発表はい

ASJC Scopus subject areas

  • 分子生物学
  • 癌研究

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