Epigenetic mechanisms regulating fate specification of neural stem cells

Masakazu Namihira, Jun Kohyama, Masahiko Abematsu, Kinichi Nakashima

研究成果: Review article

61 引用 (Scopus)

抜粋

Neural stem cells (NSCs) possess the ability to self-renew and to differentiate along neuronal and glial lineages. These processes are defined by the dynamic interplay between extracellular cues including cytokine signalling and intracellular programmes such as epigenetic modification. There is increasing evidence that epigenetic mechanisms involving, for example, changes in DNA methylation, histone modification and non-coding RNA expression are closely associated with fate specification of NSCs. These epigenetic alterations could provide coordinated systems for regulating gene expression at each step of neural cell differentiation. Here we review the roles of epigenetics in neural fate specification in the mammalian central nervous system.

元の言語English
ページ(範囲)2099-2109
ページ数11
ジャーナルPhilosophical Transactions of the Royal Society B: Biological Sciences
363
発行部数1500
DOI
出版物ステータスPublished - 2008 6 27
外部発表Yes

    フィンガープリント

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

これを引用