TY - JOUR
T1 - Epigenetic mechanisms regulating fate specification of neural stem cells
AU - Namihira, Masakazu
AU - Kohyama, Jun
AU - Abematsu, Masahiko
AU - Nakashima, Kinichi
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2008/6/27
Y1 - 2008/6/27
N2 - Neural stem cells (NSCs) possess the ability to self-renew and to differentiate along neuronal and glial lineages. These processes are defined by the dynamic interplay between extracellular cues including cytokine signalling and intracellular programmes such as epigenetic modification. There is increasing evidence that epigenetic mechanisms involving, for example, changes in DNA methylation, histone modification and non-coding RNA expression are closely associated with fate specification of NSCs. These epigenetic alterations could provide coordinated systems for regulating gene expression at each step of neural cell differentiation. Here we review the roles of epigenetics in neural fate specification in the mammalian central nervous system.
AB - Neural stem cells (NSCs) possess the ability to self-renew and to differentiate along neuronal and glial lineages. These processes are defined by the dynamic interplay between extracellular cues including cytokine signalling and intracellular programmes such as epigenetic modification. There is increasing evidence that epigenetic mechanisms involving, for example, changes in DNA methylation, histone modification and non-coding RNA expression are closely associated with fate specification of NSCs. These epigenetic alterations could provide coordinated systems for regulating gene expression at each step of neural cell differentiation. Here we review the roles of epigenetics in neural fate specification in the mammalian central nervous system.
KW - Chromatin remodelling
KW - DNA methylation
KW - Epigenetics
KW - Histone modification
KW - Neural stem cell
KW - Non-coding RNA
UR - http://www.scopus.com/inward/record.url?scp=43749089566&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=43749089566&partnerID=8YFLogxK
U2 - 10.1098/rstb.2008.2262
DO - 10.1098/rstb.2008.2262
M3 - Review article
C2 - 18375376
AN - SCOPUS:43749089566
VL - 363
SP - 2099
EP - 2109
JO - Philosophical Transactions of the Royal Society B: Biological Sciences
JF - Philosophical Transactions of the Royal Society B: Biological Sciences
SN - 0962-8436
IS - 1500
ER -