Epithelial-stromal interaction via Notch signaling is essential for the full maturation of gut-associated lymphoid tissues

Yuuki Obata, Shunsuke Kimura, Gaku Nakato, Keito Iizuka, Yurika Miyagawa, Yutaka Nakamura, Yukihiro Furusawa, Machiko Sugiyama, Keiichiro Suzuki, Masashi Ebisawa, Yumiko Fujimura, Hisahiro Yoshida, Toshihiko Iwanaga, Koji Hase, Hiroshi Ohno

研究成果: Article査読

10 被引用数 (Scopus)

抄録

Intrinsic Notch signaling in intestinal epithelial cells restricts secretory cell differentiation. In gut-associated lymphoid tissue (GALT), stromal cells located beneath the follicle-associated epithelium (FAE) abundantly express the Notch ligand delta-like 1 (Dll1). Here, we show that mice lacking Rbpj - a gene encoding a transcription factor implicated in Notch signaling - in intestinal epithelial cells have defective GALT maturation. This defect can be attributed to the expansion of goblet cells, which leads to the down-regulation of CCL20 in FAE. These data demonstrate that epithelial Notch signaling maintained by stromal cells contributes to the full maturation of GALT by restricting secretory cell differentiation in FAE.

本文言語English
ページ(範囲)1297-1304
ページ数8
ジャーナルEMBO Reports
15
12
DOI
出版ステータスPublished - 2014 12 1

ASJC Scopus subject areas

  • 生化学
  • 分子生物学
  • 遺伝学

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