ERK2 mediates inner hair cell survival and decreases susceptibility to noise-induced hearing loss

Takaomi Kurioka, Takeshi Matsunobu, Yasushi Satoh, Katsuki Niwa, Shogo Endo, Masato Fujioka, Akihiro Shiotani

研究成果: Article査読

26 被引用数 (Scopus)

抄録

Extracellular signal-regulated kinase (ERK) is a member of the family of mitogen-activated protein kinases (MAPKs) and coordinately regulates a multitude of cellular processes. In response to a variety of extracellular stimuli, phosphorylation of both threonine and tyrosine residues activates ERK. Recent evidence indicates that ERK is activated in response to cellular stress such as acoustic trauma. However, the specific role of ERK isoforms in auditory function is not fully understood. Here, we show that the isoform ERK2 plays an important role in regulating hair cell (HC) survival and noise-induced hearing loss (NIHL) in mice (C57BL/6J). We found that conditional knockout mice deficient for Erk2 in the inner ear HCs had hearing comparable to control mice and exhibited no HC loss under normal conditions. However, we found that these knockout mice were more vulnerable to noise and had blunted recovery from NIHL compared to control mice. Furthermore, we observed a significantly lower survival rate of inner hair cells in these mice compared to control mice. Our results indicate that ERK2 plays important roles in the survival of HC in NIHL.

本文言語English
論文番号16839
ジャーナルScientific reports
5
DOI
出版ステータスPublished - 2015 11月 18

ASJC Scopus subject areas

  • 一般

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