@article{a74d9276a75044a8b0a2314d694e4d52,
title = "Establishment of a novel scoring system for colon capsule endoscopy to assess the severity of ulcerative colitis-capsule scoring of ulcerative colitis",
abstract = "Background: The usefulness of second-generation colon capsule endoscopy (CCE-2) for ulcerative colitis (UC) has not been fully demonstrated. This study aimed to develop an endoscopic severity score of UC for CCE-2. Methods: Patients diagnosed with UC were enrolled prospectively and underwent colonoscopy and CCE-2 on the same day. The collected CCE-2 videos were adopted for the development of the score. These videos were scored by 4 blinded inflammatory bowel disease experts. The items validated with the Ulcerative Colitis Endoscopic Index of Severity (UCEIS) were used as the candidate items, some of which were automatically assessed using the workstation. Each item was divided into proximal and distal parts at the splenic flexure and then individually assessed. The image readers simultaneously evaluated the inflammation severity using the visual analog scale (VAS). The descriptors that contribute to this scale were evaluated, and a model to predict the VAS was constructed. The UCEIS was scored by other endoscopists using colonoscopy videos. The correlation coefficients with fecal calprotectin, blood tests, and Lichtiger index were calculated. Results: The final scoring system was fixed as {"}vascular pattern sum (proximal + distal) + bleeding sum + erosions and ulcers sum (minimum- maximum, 0-14){"} and was named Capsule Scoring of Ulcerative Colitis (CSUC). The correlation coefficient of CSUC with biomarkers and clinical score was similar to that of the UCEIS. Conclusions: We developed a new simple score using the 3 descriptors of CCE-2.",
keywords = "Colon capsule endoscopy, Inflammatory bowel disease, Ulcerative colitis",
author = "Naoki Hosoe and Masaru Nakano and Ken Takeuchi and Yutaka Endo and Katsuyoshi Matsuoka and Takayuki Abe and Teppei Omori and Mari Hayashida and Taku Kobayashi and Atsushi Yoshida and Shinta Mizuno and Yoshihiro Nakazato and Makoto Naganuma and Takanori Kanai and Mamoru Watanabe and Fumiaki Ueno and Yasuo Suzuki and Toshifumi Hibi and Haruhiko Ogata",
note = "Funding Information: Conflicts of interest: This independent research was supported by a funding contribution from Medtronic. This independent research was supported by a funding contribution from Medtronic. Author contributions: N.H. designed the study and wrote the paper. T.A. analyzed the data. M.N., K.T., Y.E., A.Y., S.M., and M.N. enrolled patients and performed colon capsule endoscopy. T.O., M.H., K.M., and N.Y. read capsule videos. N.H. and T.Ko. read colonoscopy videos. T.Ka., M.W., F.U., and Y.S. discussed the results. T.H., and H.O. helped conceive and supervise the study. Address correspondence to: Haruhiko Ogata, MD, PhD, Center for Diagnostic and Therapeutic Endoscopy, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku, Tokyo 160–8582, Japan (hogata@keio.jp). {\textcopyright} 2018 Crohn{\textquoteright}s & Colitis Foundation. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. doi: 10.1093/ibd/izy193 Published online 26 May 2018 Publisher Copyright: {\textcopyright} 2018 Crohn's & Colitis Foundation. Published by Oxford University Press. All rights reserved.",
year = "2018",
month = dec,
day = "1",
doi = "10.1093/IBD/IZY193",
language = "English",
volume = "24",
pages = "2641--2647",
journal = "Inflammatory Bowel Diseases",
issn = "1078-0998",
publisher = "John Wiley and Sons Inc.",
number = "12",
}