Establishment of an immortalized human endometrial stromal cell line with functional responses to ovarian stimuli

Munehiro Yuhki, Takashi Kajitani, Takakazu Mizuno, Yuko Aoki, Tetsuo Maruyama

研究成果: Article査読

19 被引用数 (Scopus)

抄録

Studies on the mechanisms of decidualization and endometriosis are often hampered by lack of primary endometrial cells. To facilitate in vitro studies, we established a human endometrial stromal cell line, KC02-44D, immortalized with human telomerase reverse transcriptase. Upon exposure to ovarian stimuli, KC02-44D cells showed similar cytoskeletal marker or gene expression and biochemical phenotype to primary endometrial stromal cells. KC02-44D would be useful for studies of human endometrial function and its associated pathologies.

本文言語English
論文番号104
ジャーナルReproductive Biology and Endocrinology
9
DOI
出版ステータスPublished - 2011 8月 1

ASJC Scopus subject areas

  • 生殖医学
  • 内分泌学
  • 産婦人科学
  • 発生生物学

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