TY - JOUR
T1 - Estimated 24 h urinary sodium-to-potassium ratio is related to renal function decline
T2 - A 6-year cohort study of japanese urban residents
AU - Hattori, Hiroko
AU - Hirata, Aya
AU - Kubo, Sachimi
AU - Nishida, Yoko
AU - Nozawa, Miki
AU - Kawamura, Kuniko
AU - Hirata, Takumi
AU - Kubota, Yoshimi
AU - Sata, Mizuki
AU - Kuwabara, Kazuyo
AU - Higashiyama, Aya
AU - Kadota, Aya
AU - Sugiyama, Daisuke
AU - Miyamatsu, Naomi
AU - Miyamoto, Yoshihiro
AU - Okamura, Tomonori
N1 - Funding Information:
Funding: This study was supported by grants from the Regional Innovation Cluster Program, Global Type, Ministry of Education, Culture, Sports, Science and Technology; a Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science (B 16H05249, C 16K09157, C 16K09071, C 16 K09083, C 17K09224); a Grant-in-Aid for Young Scientist from the Japan Society for the Promotion of Science (B 17K15834, B 15K19232, B 16 K16618); Comprehensive Research on Cardiovascular and Life-Style Related Disease: H29–Junkankitou–Ippan–003, H30–Junkankitou–Ippan–003, H30–Junkankitou–Ippan–005, and Junkankitou–Ippan–19FA1008.
Publisher Copyright:
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PY - 2020/8/2
Y1 - 2020/8/2
N2 - The effect of the sodium-to-potassium ratio (Na/K) on renal function within the clinically normal range of renal function are limited. We investigated the effects of an estimated 24 h urinary Na/K (e24hUNa/K) on a 6-year renal function decline among 927 urban Japanese community dwellers with no history of cardiovascular diseases and medication for hypertension, diabetes, or dyslipidemia. We partitioned the subjects into quartiles according to the e24hUNa/K. The estimated glomerular filtration rate (eGFR) was calculated using the chronic kidney disease epidemiology collaboration (CKD/EPI) formula and renal function decline was defined as an absolute value at or above the third quartile of the eGFR decline rate. A multivariable logistic regression model was used for estimation. Compared with the first quartile of the e24hUNa/K, multivariable-adjusted odds ratios (ORs) for eGFR decline in the second, third, and fourth quartiles were 0.96 (95% confidence interval: 0.61–1.51), 1.06 (0.67–1.66), and 1.65 (1.06–2.57), respectively. These results were similar when the simple spot urine Na/K ratio was used in place of the e24hUNa/K. Apparently healthy urban residents with an almost within normal range mean baseline eGFR and high e24hUNa/K ratios had an increased risk for a future decline in renal function. Reducing the Na/K ratio may be important in the prevention of chronic kidney disease in its early stage.
AB - The effect of the sodium-to-potassium ratio (Na/K) on renal function within the clinically normal range of renal function are limited. We investigated the effects of an estimated 24 h urinary Na/K (e24hUNa/K) on a 6-year renal function decline among 927 urban Japanese community dwellers with no history of cardiovascular diseases and medication for hypertension, diabetes, or dyslipidemia. We partitioned the subjects into quartiles according to the e24hUNa/K. The estimated glomerular filtration rate (eGFR) was calculated using the chronic kidney disease epidemiology collaboration (CKD/EPI) formula and renal function decline was defined as an absolute value at or above the third quartile of the eGFR decline rate. A multivariable logistic regression model was used for estimation. Compared with the first quartile of the e24hUNa/K, multivariable-adjusted odds ratios (ORs) for eGFR decline in the second, third, and fourth quartiles were 0.96 (95% confidence interval: 0.61–1.51), 1.06 (0.67–1.66), and 1.65 (1.06–2.57), respectively. These results were similar when the simple spot urine Na/K ratio was used in place of the e24hUNa/K. Apparently healthy urban residents with an almost within normal range mean baseline eGFR and high e24hUNa/K ratios had an increased risk for a future decline in renal function. Reducing the Na/K ratio may be important in the prevention of chronic kidney disease in its early stage.
KW - Estimated GFR
KW - Renal function
KW - Urinary sodium
KW - Urinary sodium-potassium ratio
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U2 - 10.3390/ijerph17165811
DO - 10.3390/ijerph17165811
M3 - Article
C2 - 32796692
AN - SCOPUS:85089382379
VL - 17
SP - 1
EP - 12
JO - International Journal of Environmental Research and Public Health
JF - International Journal of Environmental Research and Public Health
SN - 1661-7827
IS - 16
M1 - 5811
ER -