Estrone and 17β-estradiol reverse breast cancer resistance protein-mediated multidrug resistance

Yasuo Imai, Satomi Tsukahara, Etsuko Ishikawa, Takashi Tsuruo, Yoshikazu Sugimoto

研究成果: Article査読

84 被引用数 (Scopus)

抄録

Breast cancer resistance protein (BCRP), an adenosine triphosphate-binding cassette transporter, confers resistance to a series of anticancer reagents, including mitoxantrone, SN-38 and topotecan. In the present study, we found that estrone and 17β-estradiol potentiated the cytotoxicity of mitoxantrone, SN-38 and topotecan in BCRP-transduced K562 cells (K562/BCRP). These estrogens showed only a marginal effect, or none, in parental K562 cells. Estrone and 17β-estradiol increased the cellular accumulation of topotecan in K562/BCRP cells, but not in K562 cells, suggesting that these estrogens inhibit the BCRP-mediated drug efflux and overcome drug resistance.

本文言語English
ページ(範囲)231-235
ページ数5
ジャーナルJapanese Journal of Cancer Research
93
3
DOI
出版ステータスPublished - 2002
外部発表はい

ASJC Scopus subject areas

  • 腫瘍学
  • 癌研究

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