The aim of this study was to validate the contemporary grading system. Our follow-up study revealed that men with Gleason score (GS) 4+5 and those with Gleason grade group 4 had a similar prognosis. However, there was a significant discrepancy in prognosis between GS 4+5 and GS 5+4 or higher. Gleason grade groups 4 and 5 in the contemporary grading system should be reviewed.
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