抄録
The involvement of reactive oxygen species (ROS) in the pathophysiology of Sjögren's syndrome (SS), an autoimmune disorder, and irradiation-induced impairments in salivary secretion has been reported. Meanwhile, the strong antioxidant astaxanthin (Ast) has been suggested to have therapeutic effects on various diseases. In the present study, we examined the ROS scavenging capacity of Ast using a human salivary gland epithelial cell line (HSY) and investigated the effects of Ast on salivary secretion in a mouse model of irradiation-induced salivary gland dysfunction. Furthermore, we performed a clinical study of Ast in six SS patients and six normal individuals, quantifying the volume of saliva secretion and the level of oxidative stress markers in the saliva. Ast partially suppressed hydrogen peroxide-induced ROS in HSY cells. The mouse model demonstrated that the preadministration of Ast resulted in the suppression of irradiation-induced hyposalivation. Furthermore, the administration of Ast appeared to increase salivary output in both the SS and normal groups. The level of oxidative stress marker, hexanoyl-lysine, in the saliva was reduced after Ast intake. These results suggest that Ast might act as an ROS scavenger, providing benefits to SS patients with impaired salivary secretion.
| 元の言語 | English |
|---|---|
| ページ（範囲） | 130-137 |
| ページ数 | 8 |
| ジャーナル | Journal of Clinical Biochemistry and Nutrition |
| 巻 | 47 |
| 発行部数 | 2 |
| DOI | |
| 出版物ステータス | Published - 2010 9 |
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ASJC Scopus subject areas
- Clinical Biochemistry
- Medicine (miscellaneous)
- Nutrition and Dietetics
これを引用
Evaluation of therapeutic effects of astaxanthin on impairments in salivary secretion. / Yamada, Takashi; Ryo, Koufuchi; Tai, Yoshinori; Tamaki, Yoh; Inoue, Hiroko; Mishima, Kenji; Tsubota, Kazuo; Saito, Ichiro.
：: Journal of Clinical Biochemistry and Nutrition, 巻 47, 番号 2, 09.2010, p. 130-137.研究成果: Article
}
TY - JOUR
T1 - Evaluation of therapeutic effects of astaxanthin on impairments in salivary secretion
AU - Yamada, Takashi
AU - Ryo, Koufuchi
AU - Tai, Yoshinori
AU - Tamaki, Yoh
AU - Inoue, Hiroko
AU - Mishima, Kenji
AU - Tsubota, Kazuo
AU - Saito, Ichiro
PY - 2010/9
Y1 - 2010/9
N2 - The involvement of reactive oxygen species (ROS) in the pathophysiology of Sjögren's syndrome (SS), an autoimmune disorder, and irradiation-induced impairments in salivary secretion has been reported. Meanwhile, the strong antioxidant astaxanthin (Ast) has been suggested to have therapeutic effects on various diseases. In the present study, we examined the ROS scavenging capacity of Ast using a human salivary gland epithelial cell line (HSY) and investigated the effects of Ast on salivary secretion in a mouse model of irradiation-induced salivary gland dysfunction. Furthermore, we performed a clinical study of Ast in six SS patients and six normal individuals, quantifying the volume of saliva secretion and the level of oxidative stress markers in the saliva. Ast partially suppressed hydrogen peroxide-induced ROS in HSY cells. The mouse model demonstrated that the preadministration of Ast resulted in the suppression of irradiation-induced hyposalivation. Furthermore, the administration of Ast appeared to increase salivary output in both the SS and normal groups. The level of oxidative stress marker, hexanoyl-lysine, in the saliva was reduced after Ast intake. These results suggest that Ast might act as an ROS scavenger, providing benefits to SS patients with impaired salivary secretion.
AB - The involvement of reactive oxygen species (ROS) in the pathophysiology of Sjögren's syndrome (SS), an autoimmune disorder, and irradiation-induced impairments in salivary secretion has been reported. Meanwhile, the strong antioxidant astaxanthin (Ast) has been suggested to have therapeutic effects on various diseases. In the present study, we examined the ROS scavenging capacity of Ast using a human salivary gland epithelial cell line (HSY) and investigated the effects of Ast on salivary secretion in a mouse model of irradiation-induced salivary gland dysfunction. Furthermore, we performed a clinical study of Ast in six SS patients and six normal individuals, quantifying the volume of saliva secretion and the level of oxidative stress markers in the saliva. Ast partially suppressed hydrogen peroxide-induced ROS in HSY cells. The mouse model demonstrated that the preadministration of Ast resulted in the suppression of irradiation-induced hyposalivation. Furthermore, the administration of Ast appeared to increase salivary output in both the SS and normal groups. The level of oxidative stress marker, hexanoyl-lysine, in the saliva was reduced after Ast intake. These results suggest that Ast might act as an ROS scavenger, providing benefits to SS patients with impaired salivary secretion.
KW - Astaxanthin
KW - Reactive oxygen species
KW - Salivary secretion
KW - Sjögren's syndrome
UR - http://www.scopus.com/inward/record.url?scp=77956575913&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77956575913&partnerID=8YFLogxK
U2 - 10.3164/jcbn.10-31
DO - 10.3164/jcbn.10-31
M3 - Article
C2 - 20838568
AN - SCOPUS:77956575913
VL - 47
SP - 130
EP - 137
JO - Journal of Clinical Biochemistry and Nutrition
JF - Journal of Clinical Biochemistry and Nutrition
SN - 0912-0009
IS - 2
ER -