Evolutionarily dynamic alternative splicing of GPR56 Regulates regional cerebral cortical patterning

Byoung Il Bae, Ian Tietjen, Kutay D. Atabay, Gilad D. Evrony, Matthew B. Johnson, Ebenezer Asare, Peter P. Wang, Ayako Y. Murayama, Kiho Im, Steven N. Lisgo, Lynne Overman, Nenad Sěstan, Bernard S. Chang, A. James Barkovich, P. Ellen Grant, Meral Topcu̧, Jeffrey Politsky, Hideyuki Okano, Xianhua Piao, Christopher A. Walsh

研究成果: Article

113 引用 (Scopus)

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The human neocortex has numerous specialized functional areas whose formation is poorly understood. Here, we describe a 15-base pair deletion mutation in a regulatory element of GPR56 that selectively disrupts human cortex surrounding the Sylvian fissure bilaterally including "Broca's area," the primary language area, by disrupting regional GPR56 expression and blocking RFX transcription factor binding. GPR56 encodes a heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptor required for normal cortical development and is expressed in cortical progenitor cells. GPR56 expression levels regulate progenitor proliferation. GPR56 splice forms are highly variable between mice and humans, and the regulatory element of gyrencephalic mammals directs restricted lateral cortical expression. Our data reveal a mechanism by which control of GPR56 expression pattern by multiple alternative promoters can influence stem cell proliferation, gyral patterning, and, potentially, neocortex evolution.

元の言語English
ページ(範囲)764-768
ページ数5
ジャーナルScience
343
発行部数6172
DOI
出版物ステータスPublished - 2014 1 1

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これを引用

Bae, B. I., Tietjen, I., Atabay, K. D., Evrony, G. D., Johnson, M. B., Asare, E., Wang, P. P., Murayama, A. Y., Im, K., Lisgo, S. N., Overman, L., Sěstan, N., Chang, B. S., Barkovich, A. J., Grant, P. E., Topcu̧, M., Politsky, J., Okano, H., Piao, X., & Walsh, C. A. (2014). Evolutionarily dynamic alternative splicing of GPR56 Regulates regional cerebral cortical patterning. Science, 343(6172), 764-768. https://doi.org/10.1126/science.1244392