An assessment method relevant to the expected clinical application of biomaterials, when they are studied for improvement of blood-surface compatibility, is established. Segmented polyetherurethane (PU) was selected for the study as a polymer substrate for surface modification. The PU modification was carried out by surface graft polymerization of the water-soluble monomers acrylamide (AAm) and dimethyl acrylamide (DMAA). The in vivo blood compatibility of polyurethane was evaluated by implanting the catheter tube in the inferior vena cava of rabbits from the femoral vein after ligation of a distal site of the exposed femoral vein.
|ジャーナル||Journal of Biomedical Materials Research|
|出版ステータス||Published - 1997 5|
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