Exchanges of polar amino acids to alanine generate platelet-activating factor receptor mutants with altered affinities to their ligand

Medicine & Life Sciences

• platelet activating factor receptor 94%
• Platelet Activating Factor 80%
• Alanine 68%
• Ligands 47%
• Amino Acids 47%
• COS Cells 26%
• WEB 2086 17%
• Phosphorylcholine 14%
• Structure-Activity Relationship 13%
• Ether 12%
• Cell Surface Receptors 12%
• Mutagenesis 11%
• Phospholipids 10%
• Guinea Pigs 9%
• Binding Sites 8%

Chemical Compounds

• Polar Amino Acid 100%
• Alanine 64%
• Ligand 29%
• Agent Interacting With Transmitter, Hormone or Drug Receptor 8%
• Acetyl 7%
• Structure-Activity Relationship 6%
• Phospholipid 6%
• Polarity 6%
• Kd 5%
• Binding Site 5%