Execution mechanisms of programmed cell death by caspase (ICE/CED-3) family proteases

Masayuki Miura, Shin Hisahara, Takashi Araki, Hideyuki Okano

研究成果: Article査読

4 被引用数 (Scopus)

抄録

Molecular genetic study of Caenorhabditis elegans revealed the cell death-executing gene ced-3. Structural and functional similarities between CED-3 and mammalian ICE family (caspase) gene products provide the evidence that mammalian caspases are common mediators in executing programmed cell death. These findings suggest that the execution mechanisms of cell death by caspase family protease may be evolutionarily conserved from worms to mammals. This report summarizes the unique properties of caspases in apoptosis.

本文言語English
ページ(範囲)66-70
ページ数5
ジャーナルHeart and vessels
12
SUPPL. 12
出版ステータスPublished - 1997 12 1
外部発表はい

ASJC Scopus subject areas

  • 循環器および心血管医学

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