TY - JOUR
T1 - Expanding the structural analysis capabilities on an Orbitrap-based mass spectrometer for large macromolecular complexes
AU - Fort, Kyle L.
AU - Van De Waterbeemd, Michiel
AU - Boll, Dmitriy
AU - Reinhardt-Szyba, Maria
AU - Belov, Mikhail E.
AU - Sasaki, Eita
AU - Zschoche, Reinhard
AU - Hilvert, Donald
AU - Makarov, Alexander A.
AU - Heck, Albert J.R.
N1 - Funding Information:
We acknowledge the support from the Netherlands Organization for Scientific Research (NWO) funding the large-scale proteomics facility Proteins@Work (project 184.032.201) embedded in the Netherlands Proteomics Centre. M. W. and A. J. R. H. are additionally supported by a Projectruimte grant (12PR3303-2) from Fundamenteel Onderzoek der Materie (FOM). K. F., A. M. and A. J. R. H. acknowledge additional support through the European Union Horizon 2020 programme FET-OPEN project MSmed, Project 686547. A. J. R. H. acknowledge further support by the NWO TOP-Punt Grant 718.015.003.
Publisher Copyright:
© 2018 The Royal Society of Chemistry.
PY - 2018/1/7
Y1 - 2018/1/7
N2 - Native mass spectrometry can provide insight into the structure of macromolecular biological systems. As analytes under investigation get larger and more complex, instrument capabilities need to be advanced. Herein, modifications to an Orbitrap Q Exactive Plus mass spectrometer that increase signal intensity, mass resolution, and maximum m/z measurable are described.
AB - Native mass spectrometry can provide insight into the structure of macromolecular biological systems. As analytes under investigation get larger and more complex, instrument capabilities need to be advanced. Herein, modifications to an Orbitrap Q Exactive Plus mass spectrometer that increase signal intensity, mass resolution, and maximum m/z measurable are described.
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U2 - 10.1039/c7an01629h
DO - 10.1039/c7an01629h
M3 - Article
C2 - 29138777
AN - SCOPUS:85038610350
SN - 0003-2654
VL - 143
SP - 100
EP - 105
JO - The Analyst
JF - The Analyst
IS - 1
ER -