Experimental measurements on phantoms and Monte Carlo simulation to evaluate the effect of inhomogeneity on optical pathlength

Eiji Okada, Michael Firbank, Martin Schweiger, Simon R. Arridge, Jeremy C. Hebden, Mutsuhisa Hiraoka, David T. Delpy

研究成果: Conference contribution

10 被引用数 (Scopus)

抄録

Determination of the optical pathlength of light in tissue is important to quantitate NIRS data. However, the inhomogeneity of the illuminated tissues increases the difficulty of determining the relevant optical pathlength in the tissue. For instance, in the head, the contribution of the tissues overlying the brain to the total optical pathlength cannot be ignored in the monitoring of cerebral oxygenation with NIRS. In this study, time-of-flight measurements of an inhomogeneous phantom are carried out in the laboratory to examine the contribution of the overlying tissue to the optical pathlength. The phantom consists of two homogeneous components, the boundaries of which are two concentric cylinders. The TPSF is measured with a picosecond laser and a streak camera, and the change of TPSF with the distance between source and detection fibers is examined. The experimental TPSF and mean time of flight are compared with the results of a Monto Carlo simulation and a finite element model based on the diffusion equation. A comparison of the accuracy of prediction of the pathlength by each model is presented as a function of the spacing between source and detection fibers. The intensity photon measurement density functions in each of the cylinders were estimated from the Monte Carlo simulations. The results provide estimates for the amount of the NIRS signal arising from overlying tissues in the head.

本文言語English
ホスト出版物のタイトルOptical Tomography, Photon Migration, and Spectroscopy of Tissue and Model Media
ホスト出版物のサブタイトルTheory, Human Studies, and Instrumentation
編集者Britton Chance, Robert R. Alfano
出版社SPIE
ページ174-181
ページ数8
ISBN(電子版)9780819417367
DOI
出版ステータスPublished - 1995 5月 30
イベントOptical Tomography, Photon Migration, and Spectroscopy of Tissue and Model Media: Theory, Human Studies, and Instrumentation - San Jose, United States
継続期間: 1995 2月 11995 2月 28

出版物シリーズ

名前Proceedings of SPIE - The International Society for Optical Engineering
2389
ISSN(印刷版)0277-786X
ISSN(電子版)1996-756X

Other

OtherOptical Tomography, Photon Migration, and Spectroscopy of Tissue and Model Media: Theory, Human Studies, and Instrumentation
国/地域United States
CitySan Jose
Period95/2/195/2/28

ASJC Scopus subject areas

  • 電子材料、光学材料、および磁性材料
  • 凝縮系物理学
  • コンピュータ サイエンスの応用
  • 応用数学
  • 電子工学および電気工学

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