Experimental prediction of the wavelength-dependent path-length factor for optical intrinsic signal analysis

Koichiro Sakaguchi, Tomoya Tachibana, Shunsuke Furukawa, Takushige Katsura, Kyoko Yamazaki, Hideo Kawaguchi, Atsushi Maki, Eiji Okada

    研究成果: Article査読

    19 被引用数 (Scopus)

    抄録

    Analysis of the optical intrinsic signal of an exposed cortex has been applied to measurement of functional brain activation. It is important for accurate measurement of concentration changes in oxygenated hemoglobin and deoxygenated hemoglobin to consider the wavelength dependence of the mean optical path lengths for the reflectance of cortical tissue. A method is proposed to experimentally estimate the wavelength dependence of the mean optical path length in cortical tissue from the multispectral reflectance of the exposed cortex without any additional instruments. The trend in the wavelength dependence of the mean optical path length estimated by the proposed method agrees with that estimated by the model-based prediction, whereas the magnitude of the wavelength dependence predicted by the proposed method is greater than that of the model-based prediction. The experimentally predicted mean optical path length minimizes the difference in the measured changes in the concentrations of the oxygenated hemoglobin and deoxygenated hemoglobin calculated from different wavelength pairs.

    本文言語English
    ページ(範囲)2769-2777
    ページ数9
    ジャーナルApplied Optics
    46
    14
    DOI
    出版ステータスPublished - 2007 5 10

    ASJC Scopus subject areas

    • 原子分子物理学および光学
    • 工学(その他)
    • 電子工学および電気工学

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