Exploring the glycan interaction in vivo: Future prospects of neo-glycoproteins for diagnostics

Akihiro Ogura, Almira Kurbangalieva, Katsunori Tanaka

研究成果: Review article査読

4 被引用数 (Scopus)

抄録

Herein the biodistributions and in vivo kinetics of chemically prepared neoglycoproteins are reviewed. Chemical methods can be used to conjugate various mono- and oligosaccharides onto a protein surface. The kinetics and organ-specific accumulation profiles of these glycoconjugates, which are introduced through intravenous injections, have been analyzed using conventional dissection studies as well as noninvasive methods such as single photon emission computed tomography, positron emission tomography and fluorescence imaging. These studies suggest that glycan-dependent protein distribution kinetics may be useful for pharmacological and diagnostic applications.

本文言語English
ページ(範囲)804-812
ページ数9
ジャーナルGlycobiology
26
8
DOI
出版ステータスPublished - 2016 8 1
外部発表はい

ASJC Scopus subject areas

  • Biochemistry

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