抄録
Immunostaining with NJ-1 monoclonal antibody (MoAb) revealed that NJ-1 is expressed on megakaryocytes (MKs). NJ-1-positive and lineage-negative progenitor cells have a higher potency to proliferate and differentiate into MKs. MKs were divided into NJ-1+MKs and NJ-1−MKs. NJ-1+MKs are immature MKs because of their low potential to generate proplatelets. When cultured CD41-positive MK cells were analyzed with RT-PCR, we found that the expression of NJ-1 is down-regulated. NJ-1+MKs have a high adherent potential to endothelial cells comparing with NJ-1−MKs, and this binding ability could be inhibited by the NJ-1-Fc fusion protein. We hypothesize that NJ-1+MKs are immature MKs and the NJ-1 molecule is involved in MK adhesion to endothelial cells.
| 本文言語 | English |
|---|---|
| ページ（範囲） | 667-674 |
| ページ数 | 8 |
| ジャーナル | Biochemical and Biophysical Research Communications |
| 巻 | 292 |
| 号 | 3 |
| DOI | |
| 出版ステータス | Published - 2002 1月 1 |
ASJC Scopus subject areas
- 生物理学
- 生化学
- 分子生物学
- 細胞生物学