Expression and function of Sox21 during mouse cochlea development

Makoto Hosoya, Masato Fujioka, Satoru Matsuda, Hiroyuki Ohba, Shinsuke Shibata, Fumiko Nakagawa, Takahisa Watabe, Ken Ichiro Wakabayashi, Yumiko Saga, Kaoru Ogawa, Hirotaka James Okano, Hideyuki Okano

研究成果: Article査読

12 被引用数 (Scopus)

抄録

The development of the inner ear is an orchestrated process of morphogenesis with spatiotemporally controlled generations of individual cell types. Recent studies have revealed that the Sox gene family, a family of evolutionarily conserved HMG-type transcriptional factors, is differentially expressed in each cell type of the mammalian inner ear and plays critical roles in cell-fate determination during development. In this study, we examined the expression pattern of Sox21 in the developing and adult murine cochlea. Sox21 was expressed throughout the sensory epithelium in the early otocyst stage but became restricted to supporting cells during adulthood. Interestingly, the expression in adults was restricted to the inner phalangeal, inner border, and Deiters' cells: all of these cells are in direct contact with hair cells. Evaluations of the auditory brainstem-response revealed that Sox21-/- mice suffered mild hearing impairments, with an increase in hair cells that miss their appropriate planar cell polarity. Taken together with the previously reported critical roles of SoxB1 families in the morphogenesis of inner ear sensory and neuronal cells, our results suggest that Sox21, a counteracting partner of the SoxB1 family, controls fine-tuned cell fate decisions. Also, the characteristic expression pattern may be useful for labelling a particular subset of supporting cells.

本文言語English
ページ(範囲)1261-1269
ページ数9
ジャーナルNeurochemical Research
36
7
DOI
出版ステータスPublished - 2011 7

ASJC Scopus subject areas

  • 生化学
  • 細胞および分子神経科学

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