Expression and localization of aquaporin-4 in sensory ganglia

Jungo Kato, Yoshiki Takai, Mariko Kato Hayashi, Yasuhiro Kato, Manami Tanaka, Yoshiro Sohma, Yoichiro Abe, Masato Yasui

研究成果: Article査読

14 被引用数 (Scopus)

抄録

Aquaporin-4 (AQP4) is a water channel protein that is predominantly expressed in astrocytes in the CNS. The rapid water flux through AQP4 may contribute to electrolyte/water homeostasis and may support neuronal activities in the CNS. On the other hand, little is known about the expression of AQP4 in the peripheral nervous system (PNS). Using AQP4-/- mice as a negative control, we demonstrated that AQP4 is also expressed in sensory ganglia, such as trigeminal ganglia and dorsal root ganglia in the PNS. Immunohistochemistry revealed that AQP4 is exclusively localized to satellite glial cells (SGCs) surrounding the cell bodies of the primary afferent sensory neurons in the sensory ganglia. Biochemical analyses revealed that the expression levels of AQP4 in sensory ganglia were considerably lower than those in astrocytes in the CNS. Consistently, behavioral analyses did not show any significant difference in terms of mechanical and cold sensitivity between wild type and AQP4-/- mice. Overall, although the pathophysiological relevance of AQP4 in somatosensory perception remains unclear, our findings provide new insight into the involvement of water homeostasis in the peripheral sensory system.

本文言語English
ページ(範囲)562-567
ページ数6
ジャーナルBiochemical and Biophysical Research Communications
451
4
DOI
出版ステータスPublished - 2014 9 5

ASJC Scopus subject areas

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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