Expression in Escherichia coli of a new multidrug efflux pump, MexXY, from Pseudomonas aeruginosa

Tomoyuki Mine, Yuji Morita, Atsuko Kataoka, Tohru Mizushima, Tomofusa Tsuchiya

研究成果: Article

208 引用 (Scopus)

抜粋

Two new genes (mexXY) similar to mexAB, mexCD, and mexEF and mediating multidrug resistance were cloned from the chromosome of Pseudomonas aeruginosa. Elevated ethidium extrusion was observed with Escherichia coli cells harboring the plasmid carrying mexXY. This MexXY system confers higher resistance to fluoroquinolones than the MexAB and MexCD systems, and E. coli TolC or P. aeruginosa OprM is necessary for the function of the MexXY system.

元の言語English
ページ(範囲)415-417
ページ数3
ジャーナルAntimicrobial Agents and Chemotherapy
43
発行部数2
出版物ステータスPublished - 1999 2 1

    フィンガープリント

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

これを引用

Mine, T., Morita, Y., Kataoka, A., Mizushima, T., & Tsuchiya, T. (1999). Expression in Escherichia coli of a new multidrug efflux pump, MexXY, from Pseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy, 43(2), 415-417.