Expression of aldosterone synthase CYP11B2 was inversely correlated with longevity

Taiki Hayashi, Zhen Zhang, Ghaith Al-Eyd, Atsushi Sasaki, Masanori Yasuda, Masafumi Oyama, Celso E. Gomez-Sanchez, Hirotaka Asakura, Tsugio Seki, Kuniaki Mukai, Koshiro Nishimoto

研究成果: Article査読

8 被引用数 (Scopus)

抄録

Immunohistochemistry of human aldosterone synthase (CYP11B2)has revealed that most of aldosterone is autonomously produced in aldosterone-producing cell clusters (APCCs)beneath the capsule of adult adrenals rather than physiologically in the zona glomerulosa (ZG). APCCs have been occasionally found to harbor a somatic mutation of ion channel/pump genes, and number and size of APCCs increase with age until 50 years old. Herein, the objective of the study was to examine APCC development in 106 autopsied adrenals from 85 elderly individuals who died at ages from 50 to 103 years. We obtained the following results: (1)physiological CYP11B2 expression in ZG were attenuated in more elderly persons; (2)number and size of APCCs decreased with age; (3)detachment of APCC from the capsule appeared to occur occasionally over the wide range of the ages; and (4)incidental micro aldosterone-producing adenomas (APAs)and possible APCC-to-APA transitional lesions (pAATLs)were found primarily in samples from persons aged 50–60 years but not in samples from more elderly persons; pAATL was a putative designation based on our previous results indicating that it consisted of subcapsular APCC-like portion and inner APA-like portions. Thus, the formation of the CYP11B2-expressing lesions as well as thickening of the ZG in the adrenals were inversely correlated with age of death in the individuals aged over 50 years. Considering that autopsy samples were used in this study, inactive production of aldosterone regardless of autonomous or physiological manners may have survival advantages in individuals aged over 50 years.

本文言語English
論文番号105361
ジャーナルJournal of Steroid Biochemistry and Molecular Biology
191
DOI
出版ステータスPublished - 2019 7月

ASJC Scopus subject areas

  • 内分泌学、糖尿病および代謝内科学
  • 生化学
  • 分子医療
  • 分子生物学
  • 内分泌学
  • 臨床生化学
  • 細胞生物学

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