TY - JOUR
T1 - Expression of atrial natriuretic factor gene in hearts from neonates of spontaneously hypertensive rats and stroke-prone spontaneously hypertensive rats
AU - Arai, Hiroshi
AU - Nakao, Kazuwa
AU - Saito, Yoshihiko
AU - Sugawara, Akira
AU - Yamada, Takayuki
AU - Itoh, Hiroshi
AU - Mukoyama, Masashi
AU - Hosoda, Kiminori
AU - Shirakami, Gotaro
AU - Morii, Narito
AU - Shiono, Shozo
AU - Ohkubo, Hiroaki
AU - Nakanishi, Shigeteda
AU - Imura, Hiroo
PY - 1988/12
Y1 - 1988/12
N2 - In order to further elucidate the expression of the atrial natriuretic factor (ANF) gene in spontaneously hypertensive rats (SHR) and the substrain, stroke-prone SHR (SHRSP), ANF messenger (m)RNA levels in the atrium and in the ventricle were measured in neonates of SHR and SHRSP and were compared with those in control Wistar-Kyoto rats (WKY). The levels of ANF mRNA in ventricles of the three strains reached approximately 7% of those in atria; however, no significant difference was observed in atrial and ventricular ANF mRNA levels among the three strains. These results demonstrate that the expression of the ANF gene in hearts from neonates of WKY, SHR and SHRSP is similar among the three strains.
AB - In order to further elucidate the expression of the atrial natriuretic factor (ANF) gene in spontaneously hypertensive rats (SHR) and the substrain, stroke-prone SHR (SHRSP), ANF messenger (m)RNA levels in the atrium and in the ventricle were measured in neonates of SHR and SHRSP and were compared with those in control Wistar-Kyoto rats (WKY). The levels of ANF mRNA in ventricles of the three strains reached approximately 7% of those in atria; however, no significant difference was observed in atrial and ventricular ANF mRNA levels among the three strains. These results demonstrate that the expression of the ANF gene in hearts from neonates of WKY, SHR and SHRSP is similar among the three strains.
KW - Atrial natriuretic polypeptide
KW - Gene expression
KW - Messenger RNA
KW - Neonate
KW - Spontaneously hypertensive rats
KW - Ventricle
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M3 - Article
C2 - 2977162
AN - SCOPUS:0024272511
VL - 6
SP - S276-S278
JO - Journal of Hypertension, Supplement
JF - Journal of Hypertension, Supplement
SN - 0952-1178
IS - 4
ER -