Expression of Biologically Active Receptors for Natriuretic Peptides in the Human Uterus during Pregnancy

Hiroaki Itoh, Norimasa Sagawa, Masaaki Hasegawa, Hidetaka Nanno, Fuminori Kobayashi, Yoshiyuki Ihara, Takahide Mori, Yasato Komatsu, Shin Ichi Suga, Takaaki Yoshimasa, Hiroshi Itoh, Kazuwa Nakao

研究成果: Article査読

46 被引用数 (Scopus)

抄録

Human amnion cells secrete a large amount of brain natriuretic peptide (BNP). In the present study, to elucidate the possible roles of amniotic BNP during the course of human pregnancy, the tissue distributions of biologically active receptors of natriuretic peptides, atrial natriuretic peptide (ANP)-A receptor and ANP-B receptor in the human uterus during pregnancy were investigated by Northern blot analysis and an in vitro guanosine 3′,5′-cyclic phosphate (cGMP) generation assay, the second messenger of natriuretic peptides, using crude membrane preparations. Both ANP-A and ANP-B receptor mRNAs were detected in the tissues of decidua vera, chorion laeve, myometrium and placenta. The in vitro cGMP generation assay revealed that the expression of ANP-A receptor was more prominent than that of ANP-B receptor in these tissues. On the other hand, in amniotic tissue only ANP-B receptor mRNA was weakly expressed but ANP-A receptor mRNA was not detected.

本文言語English
ページ(範囲)602-607
ページ数6
ジャーナルBiochemical and Biophysical Research Communications
203
1
DOI
出版ステータスPublished - 1994 1月 1
外部発表はい

ASJC Scopus subject areas

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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