Expression of c-kit receptor (CD 117) and CD34 in leukemic cells

Kazuo Muroi, Mitsuru Nakamurat, Youichi Amemiya, Toshio Suda, Yasusada Miura

研究成果: Article

26 被引用数 (Scopus)

抄録

The expression of c-kit receptor (c-kit R; CD117) and CD34 was examined in acute myeloid leukemia (AML), acute lymphoid leukemia (ALL), chronic myeloid leukemia (CML) in blastic transformation (BT), and myelofibrosis (MF) in myeloid BT. In myeloid leukemia including AML, CML-myeloid BT and MF-myeloid BT, both c-kit R and CD34 were expressed synchronously, while in lymphoid leukemia including ALL and CML-lymphoid BT, only CD34 was highly expressed. A close correlation between c-kit R and CD33 expression and an inverse correlation between c-kit R and CD 19 expression were observed when all of the myeloid plus lymphoid leukemia cells were analysed. There was a close correlation between c-kit R and CD34 expression in the myeloid leukemia cells, c-kit R expression may be associated with myeloid phenotypes of leukemic cells and may be useful for the diagnosis of myeloid leukemia. The literature of c-kit R expression in leukemic cells is reviewed here and the comparison of c-kit R and CD34 expression in normal hematopoietic progenitor cells with those on the leukemic counterparts was discussed.

本文言語English
ページ(範囲)297-305
ページ数9
ジャーナルLeukemia and Lymphoma
16
3-4
DOI
出版ステータスPublished - 1995 1 1

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

フィンガープリント 「Expression of c-kit receptor (CD 117) and CD34 in leukemic cells」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル