Expression of c-mos proto-oncogene in undifferentiated teratocarcinoma cells

Yuko Ogiso, Midori Matsumoto, Takashi Morita, Hoyoku Nishino, Akio Iwashima, Aizo Matsushiro

研究成果: Article査読

9 被引用数 (Scopus)

抄録

Proto-oncogene c-mos, the cellular homologue of the transforming gene of Molony murine sarcoma virus, has been characterized by the lack of expression in a variety of differentiated tissues, possibly because of the existence of an inhibitory upstream sequence. We detected mos-related transcripts in undifferentiated embryonal carcinoma cells of pluripotential cell line 311. The sizes of three major transcripts detected were estimated to be 1.8, 4.6 and 6.1-kilobases(kb) by northern analysis. Furthermore, these transcriptions were suppressed when the cell differentiation was induced by retinoic acid. Taken together, the results suggest that mos product plays a role in early stages of development.

本文言語English
ページ(範囲)477-484
ページ数8
ジャーナルBiochemical and Biophysical Research Communications
140
2
DOI
出版ステータスPublished - 1986 10月 30
外部発表はい

ASJC Scopus subject areas

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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