Expression of CD203c on basophils as a marker of immunoglobulin E-mediated l-asparaginase allergy

Moeko Hino, Naoki Shimojo, Hidemasa Ochiai, Yuzaburo Inoue, Kumiko Ando, Koji Chikaraishi, Setsuo Ota, Yuri Okimoto, Shosuke Sunami, Ryosuke Nakamura, Reiko Teshima, Yasunori Sato, Yoichi Kohno

研究成果: Article査読

6 被引用数 (Scopus)

抄録

Immediate allergy to l-asparaginase (ASP) is a major obstacle in treating lymphoid malignancies. ASP-specific immunoglobulin G (ASP-IgG) has been used as a surrogate marker. Recently, the CD203c-basophil activation test (BAT) was found to be useful in diagnosing IgE-mediated allergies. We compared the diagnostic utility of the CD203c-BAT to that of ASP-IgG levels in determining ASP allergies in children. Eight ASP allergic reactions occurred over 75 ASP treatment courses. The sensitivity, specificity and area under the receiver operating characteristic curve of CD203c-BAT were similar to the ASP-IgG levels (0.75 vs. 0.85, 0.82 vs. 0.78 and 0.81 vs. 0.85, respectively). Positive skin prick test results in patients with ASP allergy suggested that ASP-IgE was one of the key players in ASP allergy. A combination of the BAT with the ASP-IgG level had the highest specificity (0.95) and positive predictive value (0.62), which permitted us to identify ASP allergy more effectively.

本文言語English
ページ(範囲)92-96
ページ数5
ジャーナルLeukemia and Lymphoma
55
1
DOI
出版ステータスPublished - 2014 1
外部発表はい

ASJC Scopus subject areas

  • 血液学
  • 腫瘍学
  • 癌研究

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