Expression of CD44 splicing isoforms in lung cancers: Dominant expression of CD44v8-10 in non-small cell lung carcinomas

J. I.Ichiro Sasaki, Kenneth K. Tanabe, Kazuhisa Takahashi, Isamu Okamoto, Hisao Fujimoto, Mitsuhiro Matsumoto, Moritaka Suga, Masayuki Ando, Hideyuki Saya

研究成果: Article査読

15 被引用数 (Scopus)

抄録

We examined CD44 isoform expression in 138 frozen tissue samples, which included primary lung carcinomas, adjacent non-tumorous lung tissues and benign lung diseases, by both reverse transcriptase polymerase chain reaction (RT-PCR) and immunohistochemical analyses. CD44v8-10 mRNA and protein were dominantly expressed in non-small cell lung carcinomas (NSCLC), while non-tumorous tissues principally expressed CD44s and small cell lung carcinomas (SCLC) expressed either CD44s or no detectable CD44. These results indicate that CD44v8-10 is the dominant splicing isoform in NSCLC and can be practically utilized as a diagnostic marker and therapeutical target in NSCLC.

本文言語English
ページ(範囲)525-533
ページ数9
ジャーナルInternational journal of oncology
12
3
DOI
出版ステータスPublished - 1998 3月
外部発表はい

ASJC Scopus subject areas

  • 腫瘍学
  • 癌研究

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