Expression of cell‐matrix molecules and integrin receptors in human liver grafts during chronic rejection

Ken Hoshino, Bjorn Nashan, Gustav Steinhoff, Rudolf Pichlmayr, K. Hoshino

研究成果: Article査読

2 被引用数 (Scopus)

抄録

Abstract The inflammatory response of immune cells to target cells and cell‐matrix molecules is regulated by several receptor‐ligand molecules. As fibrosis develops in ongoing chronic rejection after liver transplantation, it is of interest to analyze patterns of integrin receptors and cell‐matrix molecules in order to study the relation between immune cells and the stromal and parenchymal cells. In the present study, we demonstrated the expression of these molecules in chronic rejected human liver grafts using immunohistochemical techniques. The results showed a differential expression and induction of integrin receptors and cell‐matrix molecules on resident liver cells, especially on sinusoids, reflecting a state of chronic inflammation and a specific interaction between integrin receptors and cell‐matrix molecules. The patterns of induced integrin receptors on graft‐infiltrating cells was closely related to the local production of cell‐matrix molecules and reflected the final sequence of a stepwise progress of the inflammatory reaction.

本文言語English
ページ(範囲)637-640
ページ数4
ジャーナルTransplant International
7
DOI
出版ステータスPublished - 1994 12月

ASJC Scopus subject areas

  • 移植

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