Expression of interleukin-6 in cerebral neurons and ovarian cancer tissue in Trousseau syndrome

S. Suzuki, K. Tanaka, S. Nogawa, A. Umezawa, J. Hata, Y. Fukuuchi

研究成果: Article査読

2 被引用数 (Scopus)

抄録

Interleukin-6 (IL-6) is reportedly increased in serum and CSF from acute stroke patients. However, the cellular origin and possible role of IL-6 in CNS after stroke are unclear. We describe a woman with recurrent stroke, disseminated intravascular coagulation (DIC) and non-bacterial thrombotic endocarditis (NBTE) caused by ovarian cancer (Trousseau syndrome). The patient died 50 days after the final episode of cerebral embolism. The immunohistochemical study revealed IL-6 protein to have been expressed both in cerebral neurons spared from ischemic insult and in epithelial cells of the ovarian tumor. We speculate that IL-6 produced in ovarian cancer may be associated with the hypercoagulable state and the development of NBTE in this patient. In contrast, IL-6 induction in cerebral neurons may contribute to the survival of these neurons after a stroke.

本文言語English
ページ(範囲)232-235
ページ数4
ジャーナルClinical Neuropathology
21
5
出版ステータスPublished - 2002 9 1

ASJC Scopus subject areas

  • 病理学および法医学
  • 神経学
  • 臨床神経学

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