TY - JOUR
T1 - Expression of MMP-1 in the capsule of thyroid cancer - Relationship with invasiveness
AU - Kameyama, K.
N1 - Funding Information:
The author is grateful for the direction of Professor Yasuhiro Hosoda, Department of Pathology, School of Medicine, Keio University, deeply indepted to Professor Isao Okazaki, Department of Community Health, School of Medicine, Tokai University and Dr. Yoshihide Otani, Department of Surgery, School of Medicine, Keio University, for support throughout the reserch, and Dr. Kunihiko Ito, Ito Hospital, for providing the surgical specimens and their clinical data. A part of this study was supported by the Keio Medical Association in 1992.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1996/1
Y1 - 1996/1
N2 - To investigate the invasive activity of thyroid cancer, an in situ hybridization study was carried out in 19 thyroid tumors, including nine papillary carcinomas, five follicular carcinomas and five follicular adenomas, by using a 35S-labeled MMP-1 (matrix metalloproteinase-1) cDNA probe. The MMP-1 gene was expressed not in the cancer cells but in the fibrous capsules of papillary carcinoma. Thyroid cancer is generally circumscribed by a fibrous capsule. We found that types I and III collagen constitute the fibrous capsule, and that the MMP-1 gene was expressed in the outer border of these sites. These findings suggest that MMP-1 plays an important role in the invasion of thyroid cancer.
AB - To investigate the invasive activity of thyroid cancer, an in situ hybridization study was carried out in 19 thyroid tumors, including nine papillary carcinomas, five follicular carcinomas and five follicular adenomas, by using a 35S-labeled MMP-1 (matrix metalloproteinase-1) cDNA probe. The MMP-1 gene was expressed not in the cancer cells but in the fibrous capsules of papillary carcinoma. Thyroid cancer is generally circumscribed by a fibrous capsule. We found that types I and III collagen constitute the fibrous capsule, and that the MMP-1 gene was expressed in the outer border of these sites. These findings suggest that MMP-1 plays an important role in the invasion of thyroid cancer.
KW - Collagenase
KW - In situ hybridization
KW - Invasion
KW - Matrix metalloproteinase
KW - Thyroid cancer
UR - http://www.scopus.com/inward/record.url?scp=0029864453&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029864453&partnerID=8YFLogxK
U2 - 10.1016/S0344-0338(96)80125-7
DO - 10.1016/S0344-0338(96)80125-7
M3 - Article
C2 - 8685037
AN - SCOPUS:0029864453
SN - 0344-0338
VL - 192
SP - 20
EP - 26
JO - Pathology Research and Practice
JF - Pathology Research and Practice
IS - 1
ER -
