Expression of Musashi-1 in the rat stomach and changes during mucosal injury and restitution

Hiroshi Nagata, Yasutada Akiba, Hidekazu Suzuki, Hideyuki Okano, Toshifumi Hibi

研究成果: Article査読

26 被引用数 (Scopus)

抄録

Musashi-1 is involved in maintenance of neural stem cells. In the rat stomach, we found some cells in the luminal compartment of the mucosa that stained positively for Musashi-1. These cells were distinct from other cells of epithelial lineage, except for parietal cells, and coexpressed HES5. The Musashi-1-positive cells exfoliated after damage, while Musashi-1 expression in neck cells were upregulated, and proliferating cells diminished before reappearing and increasing in number thereafter. We conclude that a subpopulation of parietal cells acts as a source of Musashi-1, which contributes to rapid re-epithelization by restoration of stem cells and regulation of cell differentiation.

本文言語English
ページ(範囲)27-33
ページ数7
ジャーナルFEBS Letters
580
1
DOI
出版ステータスPublished - 2006 1月 9

ASJC Scopus subject areas

  • 生物理学
  • 構造生物学
  • 生化学
  • 分子生物学
  • 遺伝学
  • 細胞生物学

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