Expression of N-cadherin and α-catenin in astrocytomas and glioblastomas

N. Shinoura, N. E. Paradies, R. E. Warnick, H. Chen, J. J. Larson, J. J. Tew, M. Simon, R. A. Lynch, Y. Kanai, S. Hirohashi, J. J. Hemperly, A. G. Menoni, R. Brackenbury

研究成果: Article査読

61 被引用数 (Scopus)

抄録

We examined levels of mRNA and protein for N-cadherin, the predominant cadherin in neural tissues, and mRNA levels for the cadherin-associated protein, alpha-catenin, in a series of gliomas and in glioblastoma cell lines. mRNA levels for N-cadherin and alpha-catenin were significantly higher in glioblastomas than in low-grade astrocytomas or normal brain, while the levels of intact N-cadherin protein were similar in glioblastomas, low-grade astrocytomas and brain. In addition, there was no consistent relationship between invasiveness and expression of N-cadherin and alpha-catenin in highly invasive vs minimally invasive tumours within the same histopathological grade. To assess further the relationship between cadherin expression and neural tumour invasion, we measured N-cadherin expression, calcium-dependent cell adhesion and motility of several glioblastoma cell lines. While all N-cadherin-expressing lines were adhesive, no correlation was seen between the level of N-cadherin expression and cell motility. Together, these findings imply that, in contrast to the role played by E-cadherin in carcinomas, N-cadherin does not restrict the invasion of glioblastomas.

本文言語English
ページ(範囲)627-633
ページ数7
ジャーナルBritish Journal of Cancer
72
3
DOI
出版ステータスPublished - 1995 9月
外部発表はい

ASJC Scopus subject areas

  • 腫瘍学
  • 癌研究

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