Expression of P-glycoprotein in adult T-cell leukemia cells

K. Yasuo, H. Shuichi, F. Tatsuhiko, Y. Akihiko, S. Tomoyuki, U. Atae, I. Kazuaki, S. Takeshi, U. Kimiharu, M. Masao, I. Minoru, A. Terukatsu, A. Shin-ichi

研究成果: Article査読

100 被引用数 (Scopus)

抄録

We have examined the expression of P-glycoprotein (P-gp) in adult T-cell leukemia (ATL) samples from 25 patients. Based on immunoblotting with a monoclonal antibody against P-gp, C219, 8 of 20 ATL patients were P-gp positive at the initial presentation. All 6 patients at the relapsed stage were P-gp positive, and refractory to chemotherapy. The expression of MDR1 mRNA in P-gp-positive ATL cells was increased at the relapsed stage of one patient. P-gp of this patient was photolabeled with [3H]azidopine and the labeling was inhibited with nimodipine, vinblastine and progesterone. These results suggest that P-gp expressed in ATL cells from patients at relapsed stage has the same binding site(s) for the drugs as that in multidrug resistant cells, and is correlated with the refractory nature of the cells to chemotherapy.

本文言語English
ページ(範囲)2065-2071
ページ数7
ジャーナルBlood
76
10
DOI
出版ステータスPublished - 1990
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 免疫学
  • 血液学
  • 細胞生物学

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