Expression of the heparin-binding growth factor receptor genes in human megakaryocytic leukemia cells

Osamu Katoh, Yutaka Hattori, Takeyuki Sato, Akiro Kimura, Atsushi Kuramoto, Takashi Sugimura, Masaaki Terada

研究成果: Article査読

21 被引用数 (Scopus)

抄録

K- sam bek, N- sam flg and FGFR3 sam3 establish gene family of the receptors for heparin-binding growth factors (HBGFs) or FGFs. These mRNAs were detected in human leukemia cells, CMK, K562 and HEL, which have megakaryocytic phenotype or the potency to differentiate into megakaryocytic lineage. In CMK cells N- sam flg transcript level was enhanced by the culture with 12-O-tetradecanoylphorbol-13-acetate (TPA). cDNA-polymerase chain reaction identified K- sam bek mRNA in human platelets, suggesting the involvement of HBGFs in megakaryocytopoiesis and functions of platelets.

本文言語English
ページ(範囲)83-92
ページ数10
ジャーナルBiochemical and Biophysical Research Communications
183
1
DOI
出版ステータスPublished - 1992 2月 28
外部発表はい

ASJC Scopus subject areas

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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