Expression of the neural RNA-binding protein Musashi1 in pediatric brain tumors

Aya Nakano, Yonehiro Kanemura, Kanji Mori, Eri Kodama, Atsuyo Yamamoto, Hiroaki Sakamoto, Yasuhiro Nakamura, Hideyuki Okano, Mami Yamasaki, Norio Arita

研究成果: Article査読

40 被引用数 (Scopus)

抄録

Musashi1 (MSI1) is an evolutionarily conserved RNA-binding protein, selectively expressed in neural stem cells (NSCs) and considered a versatile marker for normal NSCs and tumor cell diagnosis. Here, we examined MSI1 expression in primary pediatric brain tumors, medulloblastomas and ependymomas, by double immunostaining with lineage phenotypic markers (Lin). These tumors highly express MSI1 and are heterogeneous, containing both MSI1+/Lin- tumor cells in regions of relatively high cellularity and proliferative activity and MSI1+/Lin+ tumor cells in regions of lower cellularity. These findings suggest that MSI1 may be a useful marker for characterizing tumor heterogeneity and for examining in situ the analogy between normal NSCs and MSI1+ cells in pediatric brain tumors. This test could be easily applied to routine clinical diagnosis.

本文言語English
ページ(範囲)279-284
ページ数6
ジャーナルPediatric Neurosurgery
43
4
DOI
出版ステータスPublished - 2007 7月

ASJC Scopus subject areas

  • 小児科学、周産期医学および子どもの健康
  • 外科
  • 臨床神経学

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