Extensive bowel necrosis related to bevacizumab in metastatic rectal cancer patient: A case report and review of literature

Satoshi Takada, Yoshinori Hoshino, Homare Ito, Yohei Masugi, Toshiaki Terauchi, Kazuhiro Endo, Masaru Kimata, Junji Furukawa, Hiroharu Shinozaki, Kenji Kobayashi, Yoshiro Ogata

研究成果: Article査読

6 被引用数 (Scopus)

抄録

Recently, bevacizumab has become a key drug for treatment of metastatic colorectal cancer. Molecularly targeted agents such as bevacizumab can cause life-threatening adverse effects, though they are generally considered less toxic than cytotoxic drugs. Here, we review the case of a 76-year-old male rectal cancer patient with liver metastasis who suffered extensive bowel necrosis after administration of 5-fluorouracil-based chemotherapy with bevacizumab, and required a subtotal colectomy and end-ileostomy. Microscopic findings revealed extensive mucosal necrosis in the resected colon specimen and necrosis at the muscularis propria of the descending colon. Pathological findings suggested that the mucosal damage induced by chemotherapy may be exacerbated by treatment with bevacizumab, resulting in extensive necrosis.

本文言語English
論文番号hyu206
ページ(範囲)286-290
ページ数5
ジャーナルJapanese journal of clinical oncology
45
3
DOI
出版ステータスPublished - 2015 3 1

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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