Extracellular vesicle-associated MMPs: A modulator of the tissue microenvironment

Masayuki Shimoda

研究成果: Chapter

19 被引用数 (Scopus)

抄録

Extracellular vesicles (EVs) are small particles that mediate intercellular communications in local and distant microenvironments. Due to their ability to carry bioactive materials such as proteins, nucleic acids, and lipids, and to transfer their cargo into target cells, EVs are thought to be crucial mediators under pathological and physiological conditions. Recent investigations of their protein profiles have revealed the presence of metalloproteinases such as matrix metalloproteinases (MMPs) in EVs from various cell types and body fluids. Although information regarding the biological and clinical significance of MMPs in EVs is still limited, EV-associated MMPs can alter EV cargo by ectodomain shedding, exerting proteolytic activity following uptake by target cells, or directly contributing to degradation of extracellular matrix proteins surrounding cells. This review focuses on recent findings regarding EV-associated MMPs, and we further discuss their potential involvement in human diseases.

本文言語English
ホスト出版物のタイトルAdvances in Clinical Chemistry
編集者Gregory S. Makowski
出版社Academic Press Inc.
ページ35-66
ページ数32
ISBN(印刷版)9780128171431
DOI
出版ステータスPublished - 2019

出版物シリーズ

名前Advances in Clinical Chemistry
88
ISSN(印刷版)0065-2423
ISSN(電子版)2162-9471

ASJC Scopus subject areas

  • 化学 (全般)
  • 臨床生化学

フィンガープリント

「Extracellular vesicle-associated MMPs: A modulator of the tissue microenvironment」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル