Fabrication of bone like composites material and evaluation of its ossiferous ability

Noriyuki Hisamori, Megumi Kimura, Hikaru Morisue, Morio Matsumoto, Yoshiaki Toyama

研究成果: Article査読


Many kinds of materials are currently used as artificial bone substitutes. Hydroxyapatite (HA), the same as the main inorganic component of bone, is one of commonly used bio-ceramics and has excellent bioactivity and biocompatibility with hard tissues. However, it has problems as the bone filler or bone tissue-engineering scaffold due to low fracture toughness and low degradation rate. Recently, biodegradable materials for bone tissue have been developed to respond the requirement. Collagen, the same as the main organic component of bone, is biocompatible, biodegradable and promotes cell adhesion. A composites associated with HA is expected to have early osteoconduction and bone replacement ability. The present study was to fabricate bone-like composites consist of HA and collagen. Besides the ossiferous ability of the material in vivo is evaluated by using rabbits. Bone-like composites were successfully fabricated in this study, associating the collagen with HA. And the composites presented good osteoconductive and bone replacement potential.

ジャーナルInternational Journal of Modern Physics B
出版ステータスPublished - 2006 10月 30

ASJC Scopus subject areas

  • 統計物理学および非線形物理学
  • 凝縮系物理学


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