Factors associated with outcome of egg allergy 1 year after oral food challenge: A good baseline quality of life may be beneficial

Kana Hamada, Mizuho Nagao, Ryo Imakiire, Kanae Furuya, Yumi Mizuno, Yasunori Sato, Mayumi Matsunaga, Shingo Yamada, Kazutaka Nogami, Miyuki Hoshi, Taiga Kobori, Keigo Kainuma, Kazumoto Iijima, Takao Fujisawa

研究成果: Article査読


Background: Safely liberalizing the diet to include an allergenic food may accelerate resolution of food allergy. The outcome of liberalization, however, varies among patients. Methods: We conducted a prospective observational study to identify factors associated with outcome for egg allergy 1 year after oral food challenge (OFC). We enrolled children <72 months old who had egg allergy and underwent OFC for determination of the safe intake quantity of egg allergen. Each child's baseline clinical background was recorded. Caregivers used the Food Allergy Quality of Life Questionnaire-Parent Form (FAQLQ-PF) to assess their children's QoL. Dietary advice based on the OFC result was provided to support safe egg consumption. At 1 year after OFC, the quantity of egg each child safely consumed in daily life was surveyed. We classified the outcome as Successful (Group S) if the quantity increased during the 1 year, or as Unsuccessful (Group U) if it did not. Factors associated with the outcome were investigated by multivariate logistic regression analysis. Results: A total of 93 children were enrolled, and after 1 year, 57 finished in Group S and 36 in Group U. The mean FAQLQ-PF score at baseline was significantly lower (ie, a better QoL) in Group S than in Group U. Multivariate logistic regression analysis identified a good QoL and absence of comorbid asthma or atopic dermatitis as factors predicting a favorable outcome. Conclusion: QoL may affect food allergy outcome. Intervention focusing on the QoL may promote outgrowing of food allergies.

ジャーナルPediatric Allergy and Immunology
出版ステータスPublished - 2021 10月

ASJC Scopus subject areas

  • 小児科学、周産期医学および子どもの健康
  • 免疫アレルギー学
  • 免疫学


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