TY - JOUR
T1 - Factors Contributing to Residual Low Back Pain after Osteoporotic Vertebral Fractures
AU - Inose, Hiroyuki
AU - Kato, Tsuyoshi
AU - Ichimura, Shoichi
AU - Nakamura, Hiroaki
AU - Hoshino, Masatoshi
AU - Takahashi, Shinji
AU - Togawa, Daisuke
AU - Hirano, Toru
AU - Tokuhashi, Yasuaki
AU - Ohba, Tetsuro
AU - Haro, Hirotaka
AU - Tsuji, Takashi
AU - Sato, Kimiaki
AU - Sasao, Yutaka
AU - Takahata, Masahiko
AU - Otani, Koji
AU - Momoshima, Suketaka
AU - Hirai, Takashi
AU - Yoshii, Toshitaka
AU - Okawa, Atsushi
N1 - Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2022/3/1
Y1 - 2022/3/1
N2 - Although osteoporotic vertebral fractures (OVFs) are the most common type of osteoporotic fracture, few reports have investigated the factors contributing to residual low back pain in the chronic phase after OVFs by using radiographic evaluation. We examined the contribution of nonunion, vertebral deformity, and thoracolumbar alignment to the severity of residual low back pain post-OVF. This post hoc analysis of a prospective randomized study included 195 patients with a 48-week follow-up period. We investigated the associations between radiographic variables with the visual analog scale (VAS) scores for low back pain at 48 weeks post-OVF using a multiple linear regression model. Univariate analysis revealed that analgesic use, the local angle on magnetic resonance imaging, anterior vertebral body compression percentage on X-ray, and nonunion showed a significant association with VAS scores for low back pain. Multiple regression analysis produced the following equation: VAS for low back pain at 48 weeks = 15.49 + 0.29 × VAS for low back pain at 0 weeks + (with analgesics: +8.84, without analgesics: −8.84) + (union: −5.72, nonunion: −5.72). Among local alignment, thoracolumbar alignment, and nonunion, nonunion independently contributed to residual low back pain at 48 weeks post-OVF. A treatment strategy that reduces the occurrence of nonunion is desirable.
AB - Although osteoporotic vertebral fractures (OVFs) are the most common type of osteoporotic fracture, few reports have investigated the factors contributing to residual low back pain in the chronic phase after OVFs by using radiographic evaluation. We examined the contribution of nonunion, vertebral deformity, and thoracolumbar alignment to the severity of residual low back pain post-OVF. This post hoc analysis of a prospective randomized study included 195 patients with a 48-week follow-up period. We investigated the associations between radiographic variables with the visual analog scale (VAS) scores for low back pain at 48 weeks post-OVF using a multiple linear regression model. Univariate analysis revealed that analgesic use, the local angle on magnetic resonance imaging, anterior vertebral body compression percentage on X-ray, and nonunion showed a significant association with VAS scores for low back pain. Multiple regression analysis produced the following equation: VAS for low back pain at 48 weeks = 15.49 + 0.29 × VAS for low back pain at 0 weeks + (with analgesics: +8.84, without analgesics: −8.84) + (union: −5.72, nonunion: −5.72). Among local alignment, thoracolumbar alignment, and nonunion, nonunion independently contributed to residual low back pain at 48 weeks post-OVF. A treatment strategy that reduces the occurrence of nonunion is desirable.
KW - Alignment
KW - Cobb angle
KW - Nonunion
KW - Osteoporotic vertebral fractures
KW - Radiographic evaluation
KW - Residual low back pain
KW - Thoracolumbar alignment
KW - Vertebral deformity
KW - Visual analog scale
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U2 - 10.3390/jcm11061566
DO - 10.3390/jcm11061566
M3 - Article
AN - SCOPUS:85126294674
SN - 2077-0383
VL - 11
JO - Journal of Clinical Medicine
JF - Journal of Clinical Medicine
IS - 6
M1 - 1566
ER -