TY - JOUR
T1 - Family history of alcoholism and cognitive recovery in subacute withdrawal
AU - Moriyama, Yasushi
AU - Muramatsu, Taro
AU - Kato, Motoichiro
AU - Mimura, Masaru
AU - Kashima, Haruo
PY - 2006/2/1
Y1 - 2006/2/1
N2 - A family history of alcoholism has been demonstrated to be an important factor affecting cognitive function. However, no studies have yet been conducted to compare cognitive recovery of family history-positive (FH+) and family history-negative (FH-) alcoholics in the subacute withdrawal period. To tackle this problem, a neuropsychological test battery consisting of six computerized tests was administered to 19 FH+ and 20 FH- alcoholics at 2 and 7 weeks after abstinence. At 2 weeks after abstinence, overall performance of both FH+ and FH- groups was significantly poorer than that of healthy controls. At 7 weeks, these performances tended to recover, but in Trail Making A and Figure Position, performances of FH+ alcoholics remained worse than those of controls, while those of FH- alcoholics did not. Thus cognitive recovery during the subacute withdrawal period was worse among FH+ alcoholics than FH- alcoholics, and this finding should be considered when planning alcohol rehabilitation programs.
AB - A family history of alcoholism has been demonstrated to be an important factor affecting cognitive function. However, no studies have yet been conducted to compare cognitive recovery of family history-positive (FH+) and family history-negative (FH-) alcoholics in the subacute withdrawal period. To tackle this problem, a neuropsychological test battery consisting of six computerized tests was administered to 19 FH+ and 20 FH- alcoholics at 2 and 7 weeks after abstinence. At 2 weeks after abstinence, overall performance of both FH+ and FH- groups was significantly poorer than that of healthy controls. At 7 weeks, these performances tended to recover, but in Trail Making A and Figure Position, performances of FH+ alcoholics remained worse than those of controls, while those of FH- alcoholics did not. Thus cognitive recovery during the subacute withdrawal period was worse among FH+ alcoholics than FH- alcoholics, and this finding should be considered when planning alcohol rehabilitation programs.
KW - Alcoholics
KW - Cognitive recovery
KW - Executive function
KW - Family history
KW - Withdrawal
UR - http://www.scopus.com/inward/record.url?scp=33645223080&partnerID=8YFLogxK
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U2 - 10.1111/j.1440-1819.2006.01464.x
DO - 10.1111/j.1440-1819.2006.01464.x
M3 - Article
C2 - 16472363
AN - SCOPUS:33645223080
VL - 60
SP - 85
EP - 89
JO - Psychiatry and Clinical Neurosciences
JF - Psychiatry and Clinical Neurosciences
SN - 1323-1316
IS - 1
ER -