Fas ligand-mediated exocrinopathy resembling Sjogren's syndrome in mice transgenic for IL-10

Ichiro Saito, Kumiko Haruta, Misa Shimuta, Hiroko Inoue, Hiroshi Sakurai, Koichi Yamada, Naozumi Ishimaru, Hiroyuki Higashiyama, Takayuki Sumida, Hiroshi Ishida, Takashi Suda, Tetsuo Noda, Yoshio Hayashi, Kazuo Tsubota

研究成果: Article査読

91 被引用数 (Scopus)

抄録

Although IL-10 has been implicated in the pathogenesis of several autoimmune diseases, the mechanisms by which this cytokine mediates inflammatory lesions remain to be elucidated. Exocrine gland destruction is an important early step in the development of Sjogren's syndrome. To better understand the role of IL-10 in Sjogren's syndrome, we made transgenic mice in which the mouse IL-10 gene was regulated by the human salivary amylase promoter. Transgenic expression of IL-10 induced apoptosis of glandular tissue destruction and lymphocyte infiltration consisting primarily of Fas- ligand (FasL)+ CD4+ T cells, as well as in vitro upregulation of FasL expression on T cells. These data suggest that overexpression of IL-10 in the glands and their subsequent Fas/FasL-mediated bystander tissue destruction is a causal factor in the development of this disease.

本文言語English
ページ(範囲)2488-2494
ページ数7
ジャーナルJournal of Immunology
162
5
出版ステータスPublished - 1999 3 1
外部発表はい

ASJC Scopus subject areas

  • 免疫アレルギー学
  • 免疫学

フィンガープリント

「Fas ligand-mediated exocrinopathy resembling Sjogren's syndrome in mice transgenic for IL-10」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル