Fatal GVHD demonstrating an involvement of respiratory muscle following donor leukocyte transfusion (DLT)

Y. Oshima, S. Takahashi, H. Nagayama, K. Nishiwaki, Y. Kobayashi, A. Tojo, S. I. Okamoto, K. Tani, K. Ozawa, T. Wakabayashi, N. Sato, S. Kobayashi, K. Nakamura, Y. Ohya, N. Nukina, I. Kanazawa, S. Asano

研究成果: Article査読

12 被引用数 (Scopus)

抄録

A 41-year-old female patient with AML, who relapsed after an allogeneic BMT from her HLA-identical sister, was treated by a donor leukocyte transfusion (DLT). Thereafter, bone marrow aplasia accompanied by the disappearance of leukemic blasts following the GVHD was observed. The patient died of chronic GVHD with respiratory muscle involvement 19 months after the DLT. Although the DLT was considered helpful in suppressing the proliferation of the leukemic cells, it might also have caused the severe GVHD observed in this case. Efforts to separate the lymphocyte clones responsible for GVL from those for the GVHD thus appear to be necessary for the further development of the therapeutic approach, so-called DLT.

本文言語English
ページ(範囲)737-740
ページ数4
ジャーナルBone Marrow Transplantation
19
7
DOI
出版ステータスPublished - 1997 4月 1
外部発表はい

ASJC Scopus subject areas

  • 血液学
  • 移植

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